Full list of all 50 Deadpool achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox One.
Killed 4 enemies in the Tower Plaza with stealth kills
Set the Dialog Volume slider to zero
Killed a total of 15 enemies by holding cooked grenades
Played with Deadpool's junk
Completed the game on Veteran difficulty
Completed "Front Gates of EEEEEEEVIL!"
Completed "The Road to Victory"
Beat "Death, Baby" while wearing the pirate hat
Completed "Death, Baby"
Got a high score at the Carnival
Found 11 treasure chests in the darkness of the Tombs
Completed "Landed in Prison"
Heh heh, good times
Stealth Killed Sinister, in the Prison, with the Sword!
Interacted with all the ladies at the Shower Surprise Party room.
Collected 100 tacos
Completed "Genosha"
Played WTF is Cable
Slapped Wolverine a bunch of times
Completed "Taking A Chance"
Completed "Job One"
Made a thousand pancakes
Was pretty
Got off your well-toned bottom
Score a combo higher than 40 before they lock the elevators
Get from the studio lobby to the boardroom without dying in 5 minutes
Take no damage on the waterslide
Defeat Arclight while taking no damage from her slam attacks
Use all three switches, defeat the two phasers, and chase after Vertigo within 60 seconds
Shoot everything from the Wheel of Insanity (Balloons and the Cow)
Get through Toxic River without falling into or touching the water and taking damage
Get a stealth kill with every melee weapon in Sinister’s Lair without being detected
Choose the patience option all the way through the line in the Carnival
Collect all DP points and ammo in the bathroom
Shoot up the copier in the bridge offices
Complete the Breach in 10 seconds
Make it across the floating debris without falling
Complete "Front Gates of EEEEEEEVIL!" from start to finish without dying
Score a combo of 75 or more while fighting up the stairs at the "Front Gates of EEEEEEEVIL!"
Die 10 times in a row through the floating stairs
Complete "Front Gates of EEEEEEEVIL!" from start to finish using only swords and pistols
Complete the game on Ultra-Violence! difficulty
Complete "Landed in Prison" without countering any attacks
In "Genosha," reach the fan girl using only Hammers and Pulse Rifles
Purchase all Player Upgrades
Complete five Gold Challenges
Complete a Gold- or Silver-tier Challenge while countering at least 25 times
Combo an entire wave on any Gold-tier Challenge map
Upgrade all weapons to max
Bank a 300-hit combo