Full list of all 46 Devil May Cry 4 achievements worth 1,000 gamerscore. It takes around 80-100 hours to unlock all of the achievements on Xbox 360.
Defeat a total of 10,000 enemies.
Acquire 1,000,000 Proud Souls.
Clear all game modes.
Clear all Bloody Palace Mode stages.
Clear all Bloody Palace Mode stages with an S ranking.
Clear stage 90 of Bloody Palace Mode.
Clear stage 80 of Bloody Palace Mode.
Clear stage 70 of Bloody Palace Mode.
Clear stage 60 of Bloody Palace Mode.
Clear stage 50 of Bloody Palace Mode.
Clear stage 40 of Bloody Palace Mode.
Clear stage 30 of Bloody Palace Mode.
Clear stage 20 of Bloody Palace Mode.
Clear the game with Super Nero (Dante).
Clear all missions in Hell and Hell Mode.
Clear all missions in Dante Must Die Mode with an S ranking.
Clear all missions in Dante Must Die Mode.
Clear mission 11 in Dante Must Die Mode.
Clear all missions in Heaven or Hell Mode.
Clear all missions in Son of Sparda Mode with an S ranking.
Acquire all of Dante's skills.
Acquire all of Nero's skills.
Clear all missions in Devil Hunter Mode with an S ranking.
Clear all missions in Human Mode with an S ranking.
Acquire a maximum number of all items.
Acquire 1,000,000 Red Orbs.
Clear all missions in Son of Sparda Mode.
Clear mission 11 in Son of Sparda Mode.
Acquire 100,000 Proud Souls.
Clear stage 10 of Bloody Palace Mode.
Clear all missions in Devil Hunter Mode.
Clear mission 11 in Devil Hunter Mode.
Extend the Devil Trigger Gauge to maximum capacity.
Extend the Vitality Gauge to maximum capacity.
Clear all secret missions.
Defeat a total of 1,000 enemies.
Clear all missions in Human Mode.
Acquire 10,000 Proud Souls.
Complete a mission with an S ranking.
Acquire 100,000 Red Orbs.
Clear mission 11 in Human Mode.
Complete a Stylish Rank SSS (Smokin' Sick Style!!!) combo.
Defeat a total of 100 enemies.
Acquire 10,000 Red Orbs.
Complete a Stylish Rank SS (Smokin' Style!!) combo.
Complete a Stylish Rank S (Smokin'!) combo.