Full list of all 72 Fallout 3 achievements worth 1,550 gamerscore. It takes around 60-80 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there are 5 DLC packs containing 22 achievements worth 550 Gamerscore.
Collected 20 Vault-Tec Bobbleheads
Reached Level 20 with Bad Karma
Reached Level 20 with Neutral Karma
Reached Level 14 with Bad Karma
Reached Level 14 with Neutral Karma
Completed "Trouble on the Homefront"
Reached Level 8 with Bad Karma
Reached Level 8 with Neutral Karma
Completed "You Gotta Shoot 'Em in the Head"
Completed "Strictly Business"
Won 50 Speech Challenges
Placed a grenade or mine while pickpocketing
Kill all the Super Mutant Behemoths
Completed "Rescue from Paradise"
Made one of every custom weapon
Hacked 50 terminals
Completed "Scientific Pursuits"
Completed "Tranquility Lane"
Completed "The Superhuman Gambit"
Completed "Those!"
Completed "Agatha's Song"
Reached Level 20 with Good Karma
Collected 10 Vault-Tec Bobbleheads
Killed 300 people
Discovered 100 locations
Completed "Take it Back!"
Completed "The American Dream"
Completed "Finding the Garden of Eden"
Completed "Picking up the Trail"
Completed "The Waters of Life"
Completed "Tenpenny Tower"
Completed "Oasis"
Completed "The Nuka-Cola Challenge"
Completed "Big Trouble in Big Town"
Completed "Head of State"
Completed "Stealing Independence"
Picked 50 locks
Completed "The Wasteland Survival Guide"
Reached Level 14 with Good Karma
Completed "Reilly's Rangers"
Completed "Galaxy News Radio"
Completed "Following in His Footsteps"
Completed "The Replicated Man"
Killed 300 creatures
Reached Level 8 with Good Karma
Completed "The Power of the Atom"
Completed "Blood Ties"
Completed "Escape!"
Took the G.O.A.T.
Got the Pip-Boy 3000
Completed "Operation: Anchorage"
Completed "Paving the Way"
Completed "The Guns of Anchorage"
Completed "Aiding the Outcasts"
Completed "Free Labor"
Completed "Unsafe Working Conditions"
Found All 100 Steel Ingots
Completed "Into The Pitt"
Reached Level 30 with Neutral Karma
Reached Level 30 with Bad Karma
Reached Level 30 with Good Karma
Completed "Who Dares Wins"
Completed "Shock Value"
Completed "Death From Above"
Discovered all locations within Point Lookout
Completed "A Meeting of the Minds"
Completed "Walking With Spirits"
Completed "The Local Flavor"
Completed "This Galaxy Ain't Big Enough…"
Collected all Alien Captive Recordings
Completed "Among the Stars"
Completed "Not of This World"