Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Fully upgraded Heller.
Completed the game on HARD difficulty.
Heller Consumed Mercer.
Acquired all 46 upgrades through Consumes.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Defeated all Field Ops teams.
Found all BlackBoxes.
Destroyed all Lairs.
Spent at least 25 consecutive seconds in the air.
Destroyed 5 helicopters using Pack Leader.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroyed a Strike Team in 15 seconds or less.
10 or more kills using a single Bio-Bomb.
Completed all //BLACKNET dossiers.
Acquired 30 upgrades through Consumes.
Mounted a helicopter using Whipfist.
Simultaneously killed 2 Brawlers using a single Devastator.
Weaponized 10 vehicles.
Destroyed 5 vehicles using a Finisher.
Reached the highest point in the world.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
Stealth hijacked 5 tanks or APCs.
Consumed 10 //BLACKNET targets.
20 or more kills with a single Hammerfist dive attack.
10 or more kills with a single Black Hole attack.
Acquired a Mutation in each of the 5 categories.
Acquired 10 upgrades through Consumes.
Destroyed a single Lair.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Countered enemy attacks 20 times using Shield.
Dismembered a Brawler.
Triggered 50 alerts.
Deflected 5 missiles at enemies using Shield Block.
Karate kicked a helicopter.
Stealth Consumed 50 Blackwatch troopers.
Acquired 5 Mutations.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
5 consumes in 10 seconds or less.
Completed a //BLACKNET mission.
First Prototype Power aquired.
Heller met Father Guerra.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.