Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed the game on HARD difficulty.
Fully upgraded Heller.
Acquired all 46 upgrades through Consumes.
Heller Consumed Mercer.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Completed all //BLACKNET dossiers.
Mounted a helicopter using Whipfist.
Destroyed all Lairs.
Acquired 30 upgrades through Consumes.
Destroyed 5 helicopters using Pack Leader.
Spent at least 25 consecutive seconds in the air.
Defeated all Field Ops teams.
Found all BlackBoxes.
10 or more kills using a single Bio-Bomb.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Reached the highest point in the world.
Destroyed a Strike Team in 15 seconds or less.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
Stealth hijacked 5 tanks or APCs.
20 or more kills with a single Hammerfist dive attack.
Acquired a Mutation in each of the 5 categories.
Weaponized 10 vehicles.
Consumed 10 //BLACKNET targets.
10 or more kills with a single Black Hole attack.
Destroyed a single Lair.
Destroyed 5 vehicles using a Finisher.
Acquired 10 upgrades through Consumes.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Countered enemy attacks 20 times using Shield.
Simultaneously killed 2 Brawlers using a single Devastator.
Stealth Consumed 50 Blackwatch troopers.
Deflected 5 missiles at enemies using Shield Block.
Triggered 50 alerts.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Acquired 5 Mutations.
5 consumes in 10 seconds or less.
Completed a //BLACKNET mission.
Dismembered a Brawler.
First Prototype Power aquired.
Heller met Father Guerra.
Karate kicked a helicopter.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.