Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed the game on HARD difficulty.
Fully upgraded Heller.
Destroyed 5 helicopters using Pack Leader.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
10 or more kills using a single Bio-Bomb.
Destroyed a Strike Team in 15 seconds or less.
Defeated all Field Ops teams.
Acquired all 46 upgrades through Consumes.
Destroyed all Lairs.
Stealth hijacked 5 tanks or APCs.
20 or more kills with a single Hammerfist dive attack.
Heller Consumed Mercer.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Spent at least 25 consecutive seconds in the air.
Found all BlackBoxes.
Destroyed 5 vehicles using a Finisher.
Completed all //BLACKNET dossiers.
Acquired 30 upgrades through Consumes.
Weaponized 10 vehicles.
Mounted a helicopter using Whipfist.
Simultaneously killed 2 Brawlers using a single Devastator.
Reached the highest point in the world.
Stealth Consumed 50 Blackwatch troopers.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
Countered enemy attacks 20 times using Shield.
Consumed 10 //BLACKNET targets.
Acquired a Mutation in each of the 5 categories.
Destroyed a single Lair.
Acquired 10 upgrades through Consumes.
10 or more kills with a single Black Hole attack.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Karate kicked a helicopter.
Deflected 5 missiles at enemies using Shield Block.
Acquired 5 Mutations.
Triggered 50 alerts.
Completed a //BLACKNET mission.
Dismembered a Brawler.
First Prototype Power aquired.
Heller met Father Guerra.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
5 consumes in 10 seconds or less.
Completed MEET YOUR MAKER, Mercer infected Heller.