Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed the game on HARD difficulty.
Fully upgraded Heller.
Acquired all 46 upgrades through Consumes.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Heller Consumed Mercer.
Found all BlackBoxes.
Defeated all Field Ops teams.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Mounted a helicopter using Whipfist.
Spent at least 25 consecutive seconds in the air.
Acquired 30 upgrades through Consumes.
Destroyed all Lairs.
Completed all //BLACKNET dossiers.
Stealth Consumed 50 Blackwatch troopers.
Reached the highest point in the world.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
Acquired a Mutation in each of the 5 categories.
Consumed 10 //BLACKNET targets.
Destroyed 5 helicopters using Pack Leader.
10 or more kills using a single Bio-Bomb.
Destroyed 5 vehicles using a Finisher.
Acquired 5 Mutations.
Simultaneously killed 2 Brawlers using a single Devastator.
Stealth hijacked 5 tanks or APCs.
20 or more kills with a single Hammerfist dive attack.
Acquired 10 upgrades through Consumes.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Destroyed a Strike Team in 15 seconds or less.
10 or more kills with a single Black Hole attack.
Deflected 5 missiles at enemies using Shield Block.
Destroyed a single Lair.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Weaponized 10 vehicles.
Countered enemy attacks 20 times using Shield.
Triggered 50 alerts.
Completed a //BLACKNET mission.
5 consumes in 10 seconds or less.
Dismembered a Brawler.
First Prototype Power aquired.
Heller met Father Guerra.
Karate kicked a helicopter.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.