Full list of all 43 Prototype 2 achievements worth 1,000 gamerscore. It takes around 15-20 hours to unlock all of the achievements on Xbox 360.
Completed the game on HARD difficulty.
Fully upgraded Heller.
Destroyed 5 helicopters using Pack Leader.
Spent at least 25 consecutive seconds in the air.
Destroyed a Strike Team in 15 seconds or less.
Acquired all 46 upgrades through Consumes.
Defeated all Field Ops teams.
Destroyed all Lairs.
10 or more kills with a single Black Hole attack.
Found all BlackBoxes.
Heller Consumed Mercer.
Completed LABOR OF LOVE, Galloway kidnapped Maya.
Stealth hijacked 5 tanks or APCs.
Completed all //BLACKNET dossiers.
Traveled a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroyed 5 vehicles using a Finisher.
Destroyed 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Mounted a helicopter using Whipfist.
Acquired 30 upgrades through Consumes.
Countered enemy attacks 20 times using Shield.
Reached the highest point in the world.
Completed FALL FROM GRACE, Heller discovered Maya is alive.
10 or more kills using a single Bio-Bomb.
Acquired a Mutation in each of the 5 categories.
Weaponized 10 vehicles.
Consumed 10 //BLACKNET targets.
Karate kicked a helicopter.
Destroyed a single Lair.
20 or more kills with a single Hammerfist dive attack.
Simultaneously killed 2 Brawlers using a single Devastator.
Acquired 5 Mutations.
Acquired 10 upgrades through Consumes.
Completed NATURAL SELECTION, Heller killed Dr. Koenig.
Stealth Consumed 50 Blackwatch troopers.
Triggered 50 alerts.
Deflected 5 missiles at enemies using Shield Block.
5 consumes in 10 seconds or less.
Completed a //BLACKNET mission.
Dismembered a Brawler.
First Prototype Power aquired.
Heller met Father Guerra.
Completed RESURRECTION, Heller Consumed another's memory for the first time.
Completed MEET YOUR MAKER, Mercer infected Heller.