Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've killed 53,596 infected.
You've completed Story Mode on hard difficulty.
You've collected all Landmark collectibles scattered across New York City.
You've achieved a Platinum Medal for all Events.
You've achieved a rating of Gold or better in all Events.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've collected all Hint Collectibles scattered across New York City.
You've completed Story Mode without a single death.
You've acquired all upgrades available.
You've shot down 50 helicopters while driving armor.
You've completed the Supreme Hunter Boss Battle.
You've completed the Mother Boss Battle.
You've completed the Supreme Hybrid Boss Battle.
You've completed all Consume Events.
You've caught an object tossed by a Hydra; and have thrown it back.
You've discovered the history of Elizabeth Greene.
You've evaded 10 strike teams.
You've seized 50 vehicles from enemy hands.
You've consumed fewer than 10 Civilians during Story Mode.
You've acquired all nodes in the Web of Intrigue.
You've discovered the truth behind Hope, Idaho.
You've discovered what happened to Alex Mercer.
You've destroyed 2,000 vehicles.
You've infiltrated 10 Military Bases disguised as a Commander.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've destroyed 25 Infected Water Towers before they hatched.
You've completed 3 missions without causing a single Military Alert.
You've consumed 200 characters to regain health.
You've consumed 50 Web Targets.
You're now certified to drive and fly all vehicles.
It's definitely not you. You've patsied 5 military personnel.
You've completed the Specialist Boss Fight.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've killed 15 characters with a single Whipfist attack.
You've run over 500 characters in a single tank.
You've killed 50 characters in 5 seconds.
You've completed the Hunter Boss Encounter.
You've completed a mission without causing a single Military Alert.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.