Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've collected all Landmark collectibles scattered across New York City.
You've killed 53,596 infected.
You've completed Story Mode on hard difficulty.
You've caught an object tossed by a Hydra; and have thrown it back.
You've completed 3 missions without causing a single Military Alert.
You've acquired all nodes in the Web of Intrigue.
You've collected all Hint Collectibles scattered across New York City.
You've acquired all upgrades available.
You've destroyed 2,000 vehicles.
You've discovered the history of Elizabeth Greene.
You've completed all Consume Events.
You've discovered what happened to Alex Mercer.
You've shot down 50 helicopters while driving armor.
You've discovered the truth behind Hope, Idaho.
You've evaded 10 strike teams.
You've consumed 50 Web Targets.
You've infiltrated 10 Military Bases disguised as a Commander.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've completed the Supreme Hybrid Boss Battle.
It's definitely not you. You've patsied 5 military personnel.
You've destroyed 25 Infected Water Towers before they hatched.
You've completed the Mother Boss Battle.
You've completed a mission without causing a single Military Alert.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've seized 50 vehicles from enemy hands.
You've consumed 200 characters to regain health.
You've completed the Supreme Hunter Boss Battle.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've completed the Specialist Boss Fight.
You've killed 15 characters with a single Whipfist attack.
You're now certified to drive and fly all vehicles.
You've completed the Hunter Boss Encounter.
You've killed 50 characters in 5 seconds.
Web of Intrigue unlocked.
You've used the Upgrade Menu to acquire an Upgrade.
You've run over 500 characters in a single tank.
Achieve a rating of Gold or better in all Events.
Achieve a Platinum Medal in all Events.