Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've destroyed 25 Infected Water Towers before they hatched.
You've completed a mission without causing a single Military Alert.
You've acquired all nodes in the Web of Intrigue.
You've seized 50 vehicles from enemy hands.
You're now certified to drive and fly all vehicles.
You've caught an object tossed by a Hydra; and have thrown it back.
You've completed Story Mode on hard difficulty.
You've achieved a Platinum Medal for all Events.
You've completed Story Mode without a single death.
You've achieved a rating of Gold or better in all Events.
You've collected all Landmark collectibles scattered across New York City.
You've killed 53,596 infected.
You've completed all Consume Events.
You've discovered the history of Elizabeth Greene.
You've completed 3 missions without causing a single Military Alert.
You've acquired all upgrades available.
You've infiltrated 10 Military Bases disguised as a Commander.
You've discovered what happened to Alex Mercer.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed the Supreme Hybrid Boss Battle.
You've discovered the truth behind Hope, Idaho.
You've consumed 50 Web Targets.
You've collected all Hint Collectibles scattered across New York City.
You've evaded 10 strike teams.
You've completed the Mother Boss Battle.
It's definitely not you. You've patsied 5 military personnel.
You've killed 50 characters in 5 seconds.
You've completed the Supreme Hunter Boss Battle.
You've shot down 50 helicopters while driving armor.
You've destroyed 2,000 vehicles.
You've completed the Specialist Boss Fight.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've consumed 200 characters to regain health.
You've killed 15 characters with a single Whipfist attack.
You've run over 500 characters in a single tank.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.