Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've destroyed 2,000 vehicles.
You've completed all Consume Events.
You've completed 3 missions without causing a single Military Alert.
You've caught an object tossed by a Hydra; and have thrown it back.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've discovered what happened to Alex Mercer.
You've discovered the truth behind Hope, Idaho.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've completed Story Mode on hard difficulty.
You've killed 53,596 infected.
You've achieved a Platinum Medal for all Events.
You've achieved a rating of Gold or better in all Events.
You've acquired all nodes in the Web of Intrigue.
You've collected all Landmark collectibles scattered across New York City.
You've collected all Hint Collectibles scattered across New York City.
You've discovered the history of Elizabeth Greene.
You've acquired all upgrades available.
You've shot down 50 helicopters while driving armor.
You've completed the Supreme Hybrid Boss Battle.
You've consumed 50 Web Targets.
You've completed the Mother Boss Battle.
You've brought down your wrath on 25 strike teams, erasing them from existence.
It's definitely not you. You've patsied 5 military personnel.
You've consumed 200 characters to regain health.
You've completed the Supreme Hunter Boss Battle.
You've seized 50 vehicles from enemy hands.
You're now certified to drive and fly all vehicles.
You've completed a mission without causing a single Military Alert.
You've completed the Specialist Boss Fight.
You've destroyed 25 Infected Water Towers before they hatched.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've infiltrated 10 Military Bases disguised as a Commander.
You've killed 15 characters with a single Whipfist attack.
You've evaded 10 strike teams.
You've run over 500 characters in a single tank.
You've killed 50 characters in 5 seconds.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.