Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed Story Mode on hard difficulty.
You've killed 53,596 infected.
You've achieved a Platinum Medal for all Events.
You've achieved a rating of Gold or better in all Events.
You've acquired all nodes in the Web of Intrigue.
You've discovered the truth behind Hope, Idaho.
You've completed all Consume Events.
You've discovered what happened to Alex Mercer.
You've discovered the history of Elizabeth Greene.
You've shot down 50 helicopters while driving armor.
You've seized 50 vehicles from enemy hands.
You've destroyed 2,000 vehicles.
You've killed 50 characters in 5 seconds.
You've acquired all upgrades available.
You've infiltrated 10 Military Bases disguised as a Commander.
You've consumed 50 Web Targets.
It's definitely not you. You've patsied 5 military personnel.
You've completed 3 missions without causing a single Military Alert.
You've completed a mission without causing a single Military Alert.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've evaded 10 strike teams.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've completed the Supreme Hybrid Boss Battle.
You've consumed 200 characters to regain health.
You've completed the Mother Boss Battle.
You've caught an object tossed by a Hydra; and have thrown it back.
You've killed 15 characters with a single Whipfist attack.
You've completed the Supreme Hunter Boss Battle.
You've destroyed 25 Infected Water Towers before they hatched.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've collected all Landmark collectibles scattered across New York City.
You've destroyed 20 Helicopters in a single Helicopter flight.
You're now certified to drive and fly all vehicles.
You've completed the Specialist Boss Fight.
You've run over 500 characters in a single tank.
You've completed the Hunter Boss Encounter.
You've collected all Hint Collectibles scattered across New York City.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.