Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed Story Mode on hard difficulty.
You've caught an object tossed by a Hydra; and have thrown it back.
You've run over 500 characters in a single tank.
You've killed 53,596 infected.
You've collected all Landmark collectibles scattered across New York City.
You've collected all Hint Collectibles scattered across New York City.
You've acquired all nodes in the Web of Intrigue.
You've shot down 50 helicopters while driving armor.
You've discovered the truth behind Hope, Idaho.
You've achieved a Platinum Medal for all Events.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've achieved a rating of Gold or better in all Events.
You've acquired all upgrades available.
You've destroyed 2,000 vehicles.
You've completed all Consume Events.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've completed the Supreme Hybrid Boss Battle.
You've seized 50 vehicles from enemy hands.
You've discovered what happened to Alex Mercer.
It's definitely not you. You've patsied 5 military personnel.
You've completed the Mother Boss Battle.
You've completed 3 missions without causing a single Military Alert.
You've evaded 10 strike teams.
You've killed 50 characters in 5 seconds.
You've completed the Supreme Hunter Boss Battle.
You've destroyed 25 Infected Water Towers before they hatched.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You've discovered the history of Elizabeth Greene.
You've consumed 200 characters to regain health.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've infiltrated 10 Military Bases disguised as a Commander.
You've consumed 50 Web Targets.
You've completed a mission without causing a single Military Alert.
You're now certified to drive and fly all vehicles.
You've completed the Specialist Boss Fight.
You've killed 15 characters with a single Whipfist attack.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.