Full list of all 40 Prototype achievements worth 1,000 gamerscore. It takes around 35-40 hours to unlock all of the achievements on Xbox 360.
You've completed Story Mode on hard difficulty.
You've achieved a rating of Gold or better in all Events.
You've achieved a Platinum Medal for all Events.
You've consumed fewer than 10 Civilians during Story Mode.
You've completed Story Mode without a single death.
You've caught an object tossed by a Hydra; and have thrown it back.
You've completed all Consume Events.
You've completed 3 missions without causing a single Military Alert.
You've collected all Landmark collectibles scattered across New York City.
You've killed 53,596 infected.
You've collected all Hint Collectibles scattered across New York City.
You've killed 15 characters with a single Whipfist attack.
It's definitely not you. You've patsied 5 military personnel.
You've acquired all upgrades available.
You've infiltrated 10 Military Bases disguised as a Commander.
You've shot down 50 helicopters while driving armor.
You've run over 500 characters in a single tank.
You've acquired all nodes in the Web of Intrigue.
You've discovered the history of Elizabeth Greene.
You've evaded 10 strike teams.
You've discovered the truth behind Hope, Idaho.
You've discovered what happened to Alex Mercer.
You've destroyed 2,000 vehicles.
You've destroyed 20 Helicopters in a single Helicopter flight.
You've consumed 50 Web Targets.
You've completed the Supreme Hybrid Boss Battle.
You've seized 50 vehicles from enemy hands.
You've completed the Mother Boss Battle.
You've destroyed 25 Infected Water Towers before they hatched.
You've completed the Supreme Hunter Boss Battle.
You've destroyed 10 Military Bases or Infected Hives in New York City.
You've brought down your wrath on 25 strike teams, erasing them from existence.
You're now certified to drive and fly all vehicles.
You've completed a mission without causing a single Military Alert.
You've consumed 200 characters to regain health.
You've completed the Specialist Boss Fight.
You've killed 50 characters in 5 seconds.
You've completed the Hunter Boss Encounter.
You've used the Upgrade Menu to acquire an Upgrade.
Web of Intrigue unlocked.