Full list of all 60 Rocksmith achievements worth 1,250 gamerscore. It takes around 50-60 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 10 achievements worth 250 Gamerscore.
Play multiplayer with 2 guitars
Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged
Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball
Beat 150,000,000 points in the Guitarcade game: Super Ducks
Beat 10,000,000 points in the Guitarcade game: Ducks
Collect all guitars
Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash
Beat 100,000 points in a Chord Arrangement
Beat a 750 Note Streak
Reach Rank 11
Beat a 500 Note Streak
Play the Guitarcade game: Harmonically Challenged
Play the Guitarcade game: Dawn of the Chordead
Play the Guitarcade game: Super Slider
Play the Guitarcade game: Big Swing Baseball
Play the Guitarcade game: Quick Pick Dash
Play the Guitarcade game: Scale Runner
Reach Rank 10
Play the Guitarcade game: Super Ducks
Reach Rank 9
Play the Guitarcade game: Ducks
Reach Rank 8
Complete a Master Event
Collect 50 effects pedals
Reach Rank 7
Beat 100,000 points in a Single Note Arrangement
Using a mic, sing along and achieve Nice Singing
Earn all Gold Technique Medals
Earn all Bronze Technique Medals
Reach Rank 6
Reach Rank 5
Beat a 25 Chord Streak
Use the Tuner to tune to Drop-D
Beat a 5 Chord Streak
Reach Rank 4
Reach Rank 3
Beat 200,000 points in Master Mode
Beat 100,000 points in a Combo Arrangement
Reach Rank 2
Create and save a custom tone
Qualify for a Double Encore
Qualify for an Encore
Play an Event
Beat a 100 Note Streak
Visit the shop
Use the Amp
Complete Soundcheck (Reach Rank 1)
Beat 50,000,000 points in the Guitarcade game: Scale Runner
Beat 15,000,000 points in the Guitarcade game: Super Slider
Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead
Reach rank 11 on Bass
Collect all bass gear
Collect all basses
Beat 100,000 points in a Bass arrangement
Complete all Bass Technique Challenges to Gold
Complete all Bass Technique Challenges to Bronze
Earn a bass pedal, amp, or cabinet
Complete a bass event
Play a song with emulated bass using a guitar
Play a bass arrangement