Full list of all 60 Rocksmith achievements worth 1,250 gamerscore. It takes around 50-60 hours to unlock all of the achievements in the base game on Xbox 360.
The base game contains 50 achievements worth 1,000 Gamerscore, and there is 1 DLC pack containing 10 achievements worth 250 Gamerscore.
Play multiplayer with 2 guitars
Using a mic, sing along and achieve Nice Singing
Collect all guitars
Reach Rank 11
Beat 1,000,000 points in the Guitarcade game: Dawn of the Chordead
Reach Rank 10
Beat 5,000,000 points in the Guitarcade game: Quick Pick Dash
Reach Rank 9
Collect 50 effects pedals
Reach Rank 8
Complete a Master Event
Reach Rank 7
Play the Guitarcade game: Scale Runner
Reach Rank 6
Reach Rank 5
Play the Guitarcade game: Super Ducks
Beat 200,000 points in Master Mode
Play the Guitarcade game: Quick Pick Dash
Earn all Gold Technique Medals
Earn all Bronze Technique Medals
Reach Rank 4
Play the Guitarcade game: Dawn of the Chordead
Play the Guitarcade game: Super Slider
Beat 100,000 points in a Chord Arrangement
Beat 1,000,000 points in the Guitarcade game: Harmonically Challenged
Play the Guitarcade game: Harmonically Challenged
Reach Rank 3
Visit the shop
Beat a 25 Chord Streak
Beat a 5 Chord Streak
Beat 100,000 points in a Single Note Arrangement
Beat 100,000 points in a Combo Arrangement
Beat a 750 Note Streak
Beat a 500 Note Streak
Beat 10,000,000 points in the Guitarcade game: Ducks
Play the Guitarcade game: Ducks
Use the Tuner to tune to Drop-D
Play the Guitarcade game: Big Swing Baseball
Qualify for a Double Encore
Reach Rank 2
Create and save a custom tone
Qualify for an Encore
Play an Event
Beat a 100 Note Streak
Use the Amp
Complete Soundcheck (Reach Rank 1)
Beat 150,000,000 points in the Guitarcade game: Super Ducks
Beat 50,000,000 points in the Guitarcade game: Scale Runner
Beat 2,000,000 points in the Guitarcade game: Big Swing Baseball
Beat 15,000,000 points in the Guitarcade game: Super Slider
Collect all basses
Complete all Bass Technique Challenges to Gold
Complete all Bass Technique Challenges to Bronze
Complete a bass event
Earn a bass pedal, amp, or cabinet
Beat 100,000 points in a Bass arrangement
Play a bass arrangement
Play a song with emulated bass using a guitar
Collect all bass gear
Reach rank 11 on Bass