Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
100% the game!
Collect all items and unlock all secrets and endings.
Beat all 20 Challenges.
Kill Isaac with The Lost.
Kill Satan with The Lost.
Finish the game's final secret.
Kill Isaac with Maggy.
Kill Isaac with Lazarus.
Kill Isaac with Eve.
Kill Satan with Lazarus.
Kill Isaac with Samson.
Kill Satan with Eve.
Kill Isaac with Eden.
Kill Isaac with Judas.
Beat the Chest or Dark Room without taking damage.
Beat the Dark Room with Isaac.
Kill Isaac with Isaac.
Beat the Chest.
You are the best!
Beat the Caves 30 times.
Beat Cathedral 5 times.
Beat the Caves/Catacombs without taking damage.
Kill Satan with Samson.
Beat the Basement 40 times.
Beat the Dark Room.
Beat the Depths 20 times.
Kill Satan with ???.
Kill Mom's Heart 11 times.
Kill Isaac with Cain.
Kill Mom's Heart 10 times.
Beat the Basement/Cellar without taking damage.
Kill Satan with Eden.
Kill Mom's Heart 9 times.
Kill Mom's Heart 8 times.
Kill Mom using the Bible.
Kill Isaac with Azazel.
Beat the Boss Rush.
Kill Satan with Maggy.
Beat Sheol 5 times.
Beat 2 levels in a row without picking up any hearts.
Kill Satan with Judas.
Kill Mom's Heart 5 times.
Kill all 7 sins.
Kill Satan with Azazel.
Beat the Womb/Utero without taking damage.
Beat the Depths/Necropolis without taking damage.
Beat 2 levels in a row without taking damage.
Kill Satan with Cain.
Kill Mom's Heart 3 times.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Satan
Kill Satan with Isaac.
Beat the Womb for the first time,
Hold 55 or more pennies at one time.
Make 3 deals with the devil in one run.
Kill Mom.
Have 7 or more max red hearts at one time.
Have 4 or more soul hearts at one time
Collect all items and unlock all secrets
Kill The Lamb with Keeper
Kill ??? with Keeper
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Lilith
Beat Greed Mode with Azazel
The other side is calling...
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Complete ??? 3 times.
Beat everything in Hard Mode as every character.
...
RIP
Just Stop!
Uncover some lost remains..
Kill Mega Satan
Beat Delirium
Unlocked a new area
Donate 500 coins to the Greed Machine
Kill The Lamb