Full list of all 79 The Binding of Isaac: Rebirth achievements worth 1,520 gamerscore.
The base game contains 58 achievements worth 1,000 Gamerscore, and there are 3 DLC packs containing 21 achievements worth 520 Gamerscore.
Beat all 20 Challenges.
Beat the Boss Rush.
Beat the Dark Room.
Beat the Chest.
Collect all items and unlock all secrets and endings.
100% the game!
Kill Isaac with Cain.
Kill Isaac with Samson.
Kill Isaac with Eve.
Beat the Dark Room with Isaac.
Kill Satan with ???.
Kill Isaac with Lazarus.
Kill Isaac with Eden.
Kill Isaac with Maggy.
Kill Isaac with The Lost.
Beat the Chest or Dark Room without taking damage.
Kill Mom.
Kill Satan with The Lost.
Beat the Womb/Utero without taking damage.
Beat the Caves 30 times.
Beat the Basement 40 times.
You are the best!
Kill Isaac with Azazel.
Beat Cathedral 5 times.
Kill Satan with Samson.
Kill Satan with Lazarus.
Kill Isaac with Isaac.
Beat the Depths 20 times.
Kill Satan with Judas.
Kill Satan with Maggy.
Kill Mom's Heart 11 times.
Kill Satan with Eve.
Beat Sheol 5 times.
Kill Mom's Heart 10 times.
Beat the Caves/Catacombs without taking damage.
Finish the game's final secret.
Kill Mom's Heart 9 times.
Kill Satan with Cain.
Kill Mom's Heart 8 times.
Beat the Depths/Necropolis without taking damage.
Kill Mom's Heart 5 times.
Kill all 7 sins.
Kill Isaac with Judas.
Kill Mom using the Bible.
Kill Satan with Eden.
Kill Mom's Heart 3 times.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Kill Satan with Azazel.
Beat 2 levels in a row without picking up any hearts.
Kill Satan
Kill Satan with Isaac.
Beat the Womb for the first time,
Have 7 or more max red hearts at one time.
Hold 55 or more pennies at one time.
Have 4 or more soul hearts at one time
Beat 2 levels in a row without taking damage.
Make 3 deals with the devil in one run.
Beat the Basement/Cellar without taking damage.
Collect all items and unlock all secrets
Kill ??? with Lilith
Kill The Lamb with Lilith
Kill The Lamb with Keeper
Kill ??? with Keeper
Donate 1000 coins in Greed Mode
Beat Greed Mode with Azazel
RIP
...
Beat everything in Hard Mode as every character.
The other side is calling...
You are just like your father...
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Just Stop!
Kill Mega Satan
Beat Delirium
Unlocked a new area
Uncover some lost remains..
Donate 500 coins to the Greed Machine
Kill The Lamb