Level-Headed - 50g
Finish the game using Hysteria only once.
This achievement is VERY easy. Just don't use hysteria at all during your playthrough. Definitely recommend doing this on either an Easy or Normal difficulty playthrough. Instead of using hysteria, when times get tough, just die. The game will go back to your last checkpoint, and you can resume from there.
The reason that the achievement says "Only once" is because you're forced to use it once during the game, during the "tutorial." Just don't use it again, and you'll be fine.
*Edit* You're not forced to use it during the tutorial in the game, but just in case you do, that is why you are allowed to use it once and still get the achievement.