First you must change your settings to Guru difficulty (will not work on any other setting). You change the settings when you first start your game.
I found the games easiest to win with1 opponent (Lost about 1 out of every 4-5.games, which wasn't bad)
Domino set to 9 (aim for getting more points faster
Starting hand 7 (more chances to get big points early)
Winning score to 100
Spinner on
You can check your progress by going to the Help & Options and going to My Stats