This can be done in any game you don't simulate, including My Player, as long as you don't simulate while you are subbed out. Sliders may also be used both to help you fall behind if you just want to let the game play itself in 'coach mode' and to pull yourself out of the hole. You can also use 2 controllers to really control the game.
------------------------------>Set it up for 7 minute quarters no matter the gametype
Personally I did this during an Association game to count towards the 30 games needed to be played in my conquest for:
The Home Court achievement in NBA 2K11 worth 111 pointsEarn the NBA's best record in The Association mode (at least 30 games played). You can make your comeback until you're even and make a the game winning shot with no time left to get:
The Buzzer Beater achievement in NBA 2K11 worth 48 pointsMake a game winning shot with no time left on the clock, in a non-simulated game. Also I quit and saved with 1 minute left when I was 3 points down so that I could load and be set up for:
The Not Over Yet achievement in NBA 2K11 worth 75 pointsMake a 3 pointer at the end of regulation to send the game into overtime, in a non-simulated game. So there you have it, 3 achievements and 1 association win out of one 28 minute game instead of playing through three different 20+ minute games.