This can be very annonying without 4 controllers. Guitar Hero/Rock Band guitars/drums work as conrollers, so round up 4 of them. The game will automatically go into the remix version of the game. Now simply go for the combo cards with your profile and with the other 3 controllers, just pick a card and discard it every time. Even doing this you could get screwed over with large straights and yahtzee's, but I got it on my first try.