Chose either Ed Reed or Troy Palumalu. Sean Taylor is ok, but those two are the best. Go against a team who has a wide receiver or running back as their first player, because they have the worst tackling, like chargers, 49ers, Giants, Lions, Rams, texans, bills, etc. Mix up which direction you go, and if using a bigger safety like Reed, you can hold A and just run into the other guy. You may still have to do a reversal though.
Make a two man team. Either use Reed and a linebacker/receiver or Palumalu and Taylor. Tell the other player on your team to line up either left or right, and once you get going wait until he engages in a block, then turbo into the end zone. I didn't even have to use a reversal with this option.