To earn this achievement, you must complete the following goals:
Complete a stage
Destroy 200 enemy units
Empty 3 full capsules
Deploy 5 sub-weapons
Simply start out by completing the Prologue on your favourite difficulty, making sure to empty your capsule once and fire your sub-weapon all four possible times.
After this, you only need to kill a few more enemies, fire one sub-weapon and empty two full capsules - this comes naturally by playing through the first stage.