To unlock 'Wrong Hands' you must complete ACT 2 within the game. This is story related, and can't be missed.
Act 2 starts after Act 1with the quest 'Enter the Lawkeeper', and takes place in the territory of Madera.
You do not need to complete any challenges, rampages, time trials or side missions. You only need to complete the MAIN MISSIONS.
The quests you must complete, in order, are :
Enter the Lawkeeper
Hell of a Day
Collateral Damage Expected
A Faustian Bargain
Major Miner Rescue
Safe No More
Follow Cass's Lead
Breaking into San Quentin
Once you finish 'Breaking into San Quentin' your achievement will unlock.
There is a quest after Breaking into San Quentin' called 'Down at the Docks' which is listed as Act 2, but it is a transitional quest leading from Act 2 to Act 3. Your achievement pops before this quest is started, as noted above.
Any questions, just ask.