You can achieve this on the easiest difficulty.
Stick with sais and shotguns or hammer and pulse rifle and it should be easy. Or which ever weapons you decided to power up. The key will be to finish of the enemies as quickly as possible so it will definitely help if you have the critical strike power ups equipped too.
Also, make sure to have the multi-evade. When your health is low just teleport around the area to get your health back up.
Lastly, don't forget to use your bear traps for large enemies and land mines & grenades for blitz attack by a group of enemies.
Edit: if you die you can always back out an start from the beginning.