I personally didn't want to endure El Inferno on Hard Mode so I did a Normal Playthrough on 100% then went on to do a Hard Run as quick as I could.
If you do not want to do Normal First you can use FailedSeppuku's Solution
Up, Up, Down, Down, Left, Right, Left, Right, Y, Y, View (which would be the Back Button on 360)
Seems the patch now made it Left, Right, Left, Right, X, Y, X, X then View.
I saw somewhere (I forget which site) to use the Pollo Suit as it provides Health Regeneration... I'm not so sure it really helped but I used it anyways.
I just ran through and grabbed all the easiest to grab Collectibles on my way to the end. I recorded my run through if you guys would like to see what to expect.
Mostly a few areas have added Buzz Saws. The game doesn't get too difficult. Use INTENSO often and upgrade it as soon as you can.
Good or Bad ending will pop the achievement. I didn't grab any Orbs and just ran straight to the ending. A Good ending is all collectible 6 orbs collected and then the final 7th from the Final Boss collected.
A playlist of every video can be found here http://www.youtube.com/playlist?list=PL2TQ8dA8Rd-VTppHgsaQ-b...