As the description reads;
"Complete the final Ancestor with at least 1 relic in Regular or Hardcore difficulty."
Idea is to just complete the last of the extinction episodes "Nemesis".
little strategies;
Build the NX-1 Disruptor to destroy ancestor shields, the schematic can be found after opening the north facing gate at the beginning of the level.
Stick together! - its easy to separate on Nemesis to the many doors and generators.
Activate Traps if able - alot of the time you will have dive bombers after you, having the maps tesla traps active may save a life.