There are 5 chapters you'll need to get through to complete this game.
Chapter 1: The Rescue
Chapter 2: The Restoration
Chapter 3: The Riddle
Chapter 4: The Reckoning
Chapter 5: The Race
For the most part it's a pretty easy game to get through, just long and repetitive.
If you do get stuck on any level, I recommend taking a break and returning later.
If you're unsure what to do to get through a room press
This will give you the challenge objectives to get through.
If that doesn't help this guide might:http://www.gamefaqs.com/xbox/914939-grabbed-by-the-ghoulies/...
All credit to ZoopSoul for his guide.
Death appearing doesn't necessarily mean it's game over, quite often you can run around him and escape, try to get enemies between him and you to help with this tactic.
If you are really struggling leave a comment and I'll see if I can help