Busting two people in the same hand is akin to knocking them out of the game and causing them to leave. This typically happens when the stakes at so good people tend to go all-in. Its easy to get carried away trying to do this, the best advice is to fold before things get out of hand if you don't have anything or if the cards on the table don't reflect what you were hoping them to. A 3 of a kind or higher in my opinion would be something worth trying to bluff people into going all in on so you can bust them. A flush or a full house would also typically be good hands to work with.
To see this in action, check out YouTuber "Ratty's XBOX Achievement Guides" 's video over it happening.