Can not be missed. Achievement is awarded during natural story progression.
*** Spoiler - click to reveal ***Player must race against the clock, to prevent Frank from stopping Jack's heart. There is no time limit, however, every time Frank uses the attack, Jack's health shrinks. It is possible to have your health low enough to be one hit. Player must locate as instructed by Tenenbaum the Lot 192 remedy. 2 vials of the remedy must be located.
1. Mercury Suites -Located in Olympus Heights. Follow the locked elevator (Password 5744) up to Yi Suchong suite. Located in the library portion of the suite on the second floor. When the player drinks the first antidote the player will break Fontaine's mind control over jack. However, the players plasmids will randomly cycle and only one random can be used until the second antidote is located. Gatherer's Garden will be closed until the second antidote is located.
2. Dr. Suchong's Free Clinic- Located in Apollo Square. Upon finding the second antidote, the story progress and Jack is completely healed of the side-effects of both mind control and Lot 192.