This is a guide to fully complete the game Prey. I will be showing you how to obtain all of the game's achievements and trophies, including the collectibles for: Press Sneak, Missing Persons, Psychometry, Dear Future Self, Black Market, and TranStar Gourmand. I'll also show you how to save and kill everyone (in separate playthroughs of course) for I and It, Do No Harm, and I and Thou. In the first playthrough, I'll be showing you all of the collectibles, all miscellaneous achievements, and completing the game with no kills and in the "most empathetic" way as well as using no Neuromods for the No Needles achievement/trophy.
Afterward, I will show you where to find all of the crewmates on your second playthrough and how best to kill them for I and It and Awkward Ride Home.
**Note that for Split Affinity, you will need to reload at the end of your first playthrough and use one Typhon neuromod, then complete the last few seconds again to get that to count as your first playthrough. Then, complete your second playthrough in a new campaign slot, and make sure that you only use human neuromods throughout that playthrough.
For the I and It playthrough, be sure to keep saves outside of major areas so that you can reload if any NPCs die without you having personally killed them. There will be 42 people you need to kill, so keep checking your tracker to make sure that the count adds up.