BST99/DNC49 with -PDT axes and either a DipperYuly or NurseryNazuna jug pet can solo the majority of these quests. San d'Oria can be completed during the full Mission playthrough as this is the central storyline. Windurst can be solo'd easily except for Howl from the Heavens which may require outside help, more info on wiki. Bastok is time consuming with "wait until next game day" requirements and a mess of doors in Castle Zvahl Keep near the end. With the release of the Voidwatch system it is now easy to travel between main cities by Retrace then Atmacite Refiner teleports. Time requirements aside the story is very good and the cutscenes make it worthwhile.