This will NOT unlock in Story Mode, or Battle Mode (Vs AI or 2nd Controller).
Easiest way to do this achievement is to use any character you like, go into Arcade Mode, and use any Infinity Stone you want till you build up your meter (I recommend combining this with your finishes and using the Mind stone as the Storm on this makes your HC Gauge Rise Continuously). When charged above 50%, hit LB and RB to trigger the Infinity Storm. Do this 50 times and Ding!