This achievement is story related and cannot be missed.
Note: this must be done on the solo campaign only.
Continuing on from 'Walk the Path' achievement...
When you get halfway through level 3 on the resistance meter while exploring Faith's region your screen will go sparkly and then white for the 3rd and final time. There will be another cutscene with some interaction. When the cutscene finishes and you wake back up the achievement will unlock. This time the mission is called 'Ignorance of Bliss'.