This scenario is a little tough. You start out with 3 Survivors that have stars on the card, they are your family and you have to protect them. The scenario is much like classic mode but you must make sure no harm comes to your family cards. The can die randomly whilst scavenging, as sacrifices to use certain cards/buy ideas, or they can be killed by combat events like wolves.
If any family member dies, the scenario ends immediately
Take note of the symbols on cards, if there is a person icon, you can use your family cards safely. If there is a person icon with a line through it, using them will kill them, so avoid using your family on these cards and events.
You may want to avoid using the scavenge ability with your family, doing so can randomly kill them. I used it a few times in the early part of the run to get some expendable survivors and becuase it was not a big deal to start over that early.
The leader has a good ability in that he can take one damage to remove two fatigue. It is good to use, but make sure you have enough health to take damage from combat events if you need to since you can't sacrifice your family if they are the only survivors you draw
I would tend to use the family for the travel requirements, just to keep them safe and out the way
Other than that, it's a pretty normal run