4 cell difficulty is sort of easier than 3 cells since almost all enemies teleport right next to you the moment they're aggro'd making them easy to pick off one by one. You'll still die in 2-3 hits and can only gain flask recharges from food shops so beating the game on these difficulties is sort of ridiculous when you have to restart the game every time you die.
The final boss with 4 stem cells in particular is so annoying and difficult, he will likely make your vascular system explode with the might of 1000 suns before you finally beat him
Thankfully there's an exploit that makes doing this, and any other super difficult achievement in this game possible. Playing the game with 4 stem cells is frustrating.
Dead Cells has a sort of quick save/save state system. This is at any time you press
, the game will save at exactly that point wherever you are. The moment you die, this save feature is disabled so if you press
, dashboard, and quit the game you will continue off the last time you pressed
while alive. If you never did, you will restart at the very start of whatever level you made it to. This trick will allow you to retry for the no-hit achievement without having to restart from the beginning of the game. note:
be very careful about pressing
so you don't create a spot where you are about to be killed. Make sure you are completely dead before dashboarding to avoid doing that.
This is kind of cheating since you'll have infinite continues as long as you don't screw yourself over saving in a bad spot, but good god is this game frustrating as hell with 3 or 4 stem cells active. I managed to get this achievement abusing this exploit, but I was still pulling my hair out most of the way.