First you must make sure your settings are set at Master difficulty (will not work with any other setting). You change this when you first start your game.
I found the games easiest to win with1 opponent
Domino set to 9'(aim for getting more points faster
Starting hand 7 (more chances to get big points early)
Winning score to 100
Spinner on
You can check your progress by going to the Help & Options and going to My Stats