To earn, you must have a game with at least 10 in four of these categories: Point, Rebounds, Assists, Blocks, Steals. This achievement will pop mid game, once the stat line reflects the quadruple double.
This achievement must also be done once you are in the NBA, regular season or playoffs. You cannot earn this while doing the prelude or testing the build.
This achievement isn't as hard as it may seem, but that is dependent on what type of build you use in MyCareer.
I earned this by using my Center build by getting points, rebounds, assists, and blocks
(I think blocks are easier than steals because of the possibility of a reach in foul.)
To explain what type of center build I used, I used the max height (7'3") and max weight (290) build for a Glass-cleaning Lockdown. I also used max wingspan and shoulder width. Having your player as big as possible really helps with getting rebounds and blocks, as well as being able to score on smaller defenders. This build is also one of the best builds for park, but I think it's by far the easiest for the achievement.
When choosing my cap levels, I put everything in defensive rebounding, offensive rebounding, blocks, standing dunk, and shot close. Of course you can mess around with other stats, but I found at least these 5 are essential to having a build that can score and mainly rebound/defend. I also gave him the glass-cleaning takeover badge because it makes it easier to fill up your takeover meter and eventually get team takeover.
Badges that are very useful for this achievement are: Hustle Rebounder, Intimidator, and I didn't have Rim Protector at the time, but I could only assume that would also help greatly. Also have them all at Hall of Fame level. (Note: These badges certainly help, but it is not impossible without)
I was playing this on Hall of Fame difficulty when I earned it, but I would assume it would be easier to get blocks on Pro difficulty. Do this on 12 minute quarters. You want as much time in game to achieve it. You will also most likely need to be a starter getting 25+ minutes per game. Again, for my time being played.
Blocks is the only stat that is "out of your control". By control, I mean that you can manipulate the other stats easily, for blocks, you just need to be lucky that the enemy AI is driving to the paint and you can help defend and trigger a block. Points are easy, rebounding is very easy from the center position, and assisting gets very easy after you score a lot in the game. Normally after 25-30 points, the enemy defense will start double teaming you. Stand at the perimeter and wait for the open man to cut. You can also run plays during team takeover to grab easy assists to your teammates.