This is progress-related and can't be missed.
*** Spoiler - click to reveal ***At the start of the game you will be chased by a swarm of ravenous beetles. You'll arrive at another farmhouse and run through a door to find a large crate with a red string around it by the door, which has a red pull-handle. Climb on the crate and jump to pull the handle, shutting the door and blocking the beetles' access to your delicious body.