get ready for a bunch of boss battles in a row, with no saves between them. this achievement will unlock after beating the string of bosses on the 100th floor of the tower.
hopefully you have stocked up and assigned a large number of healing items to your quick select menu during battles. what worked best for me was the parry combined with vorpal strikes. also make sure to utilize the combination attacks during the battles where you aren't alone. I was level 18 and would recommend a little higher level if possible