Not missable
Chapter 10: Room Service
Cleaning Up
Falcone wants Clemente dead once and for all. You an Joe will be tasked with doing the dirty work: destroying Clemente's hotel conference room. To sneak in you'll need to disguise yourself as hotel janitors. Joe has a man inside, but he seems to be running late. If you don't feel like waiting, move around to the left side and take the second door. Avoid any mafia guards that might stroll by and open the door Joe is waiting behind. Once you've met back up with your ally, take a right and change into your new uniform. Move down the hall to the elevators and one of Clemente's guards will show you to a messy carpet.
Joe will arm up the bomb, but you'll still need to keep your idenity secured. Avoid any gansters that might recognize you and clean up the stains on the floor.
Roof Rumble
Clemente's gang will have secured the roof. Joe will hand you a new type of pistol with quick fire, however its clip is rather small. Thankfully, a number of the enemies carry tommy guns, which will make excenlent additions to your arsenal.
There are both enemies on the top and bottom. As you make your way to the higher levels, more mobsters will appear below. They won't ascend up towards your level, so take cover and shoot them from a far.
Once the opposition is cleared, move over to the window washer crane and activate the machine. There is a collectable sitting on top, so be sure to grab it. Ride the platform down and watch the fireworks. Lucky for Clemente, he wasn't near the blast, but now you'll really need to finish the job.
Chasing Clemente
Clemente will have already made a break for it. You'll be ambushed by a wave of mobsters toting Thompson machine guns. The first will be out in the open, so kill him with a clean headshot. The others will have taken cover behind glass walls, so duck behind the bar and take your time executing them.
Take the elevator down to the lower levels. Here there are more enemies, but on the ground level and on catwalks above. There plenty of collectables around, so even during the heavy gun fighting you'll want to stop and grab them. Joe is capable enough to cover you during this time.
Clemente will make an escape for his car and will be escorted by a second set of wheels. You'll need to keep on the enemy's tail while gun shoots them. He'll be able to destroy the escort fairly quickly
Joe's Mess
Seems Joe is a little shaken up and will end up killing an innocent bartender. Drag the corpse to the back ally and load it into a car. Get inside and drive Joe back to his place. However, the cops will be quickly on your trail. Since you can't switch cars, you'll need to outrun the police at top speed. If you really want to get the cops off your back, you can pay a large bribe of several hundred dollars to end their pursuit.
Once Joe is safely home, take the car to Mike's junkyard and destroy it with the car crusher. Steal a second car and head to your house, ending the chapter.
Source:
http://www.gamespot.com/features/6274410/p-11.html