I love the topic!
I'd have to add Lord Gwyn from dark Souls for QB to my team as well as Faith from Mirror's Edge for her running game. Especially when she has plenty of room to work. Imagine her PR/KR yardage as she hopped from shoulder pad to shoulder pad.
Edit: Nope, I changes my mind about Gwyn. Give me an o-line of Black Knights, with halberds.
My teeth taste funny today. They seem more jagged than normal.