I finally got 3 bios on Pirate Plague with Prion. This is what I did to get me past the hump finally :
"Start in China and evolve:
Rash
Sweating
Skin Lesions
Coughing
Sneezing
Air I and II
Cold Resistance I
Drug Resistance I
Water I and II
Extreme Bioaerosol
Heat Resistance I
Cold Resistance II
Rodent I
Drug Resistance II
Devolve any lethal symptoms that mutate and SAVE once China is infected. If Philippines isn't infected within a month, reload the save. Now keep an eye on New Guinea. No boats? Load and try again.
Madagascar...
Greenland...
Caribbean..."
I used this to a point. All worked well until I paid too much attention to getting the Philippines within 1 month of China getting fully infected. I paid more attention to the islands as a whole (mainly Greenland, Madagascar and Caribbean.)
Once I got it down to 1 left I made a save. I then went to the symptoms :
" Evolve:
'(Immune Supression, needed for Total Organ Failure)'
Total Organ Failure
Necrosis
Hemorrhagic Shock
Internal Hemorrhaging"
Here is where I made it slightly easier for myself again. I also evolved :
Coma-(drastically more Severe, somewhat Lethal, but more importantly harder to cure)
Paralysis-(higher Severity and slight impact on Infectivity and Lethality, but again, harder to cure)
Inflammation-(slight raise to all 3)
Seizures-(slight raise to all 3)
Insanity-(*My Severity was maxed, not sure there*, increases Infectivity but better yet again, harder to cure)
The rest of my DNA then went to :
Genetic Hardening 1 & 2
Genetic Reshuffle 1 & 2
and whatever I could after that for more Lethality (was less then 1 month left at that point)
Hope this helps anyone looking for some more tips, it worked for me.
Edit:
Final stats :
Time :497 days
Cure Progress : 27%
Score : 67,448
Dead Rising Survivalist:
17d 07h 01m 34s (PS4 ; 2nd), 17d 07h 01m 36s (Xbox One ; 1st) Xbox 360 : 17d 07h 00m (hacked leaderboard)