It's not too difficult to 100% this game. There are difficulty-related achievements but the Hard difficulty isn't much different from Normal except during the final boss fight. There are achievements for usage of your powers which you'll usually get through normal play.
At the end of some Acts in the game, you'll play a "Junction" chapter where you can decide between 2 storylines. Preview and then pick one of them, wait for the achievement to unlock and then hit

and reload from checkpoint to go back and pick the other choice.
It's better to get the collectibles during your first playthrough but, if you miss any, there is a chapter select so you can go back. Keep an eye out for collectibles by using

to activate Time Vision or following the guide:

The Media Baron achievement in Quantum Break worth 49 pointsYou need to find all Emails, presentations, TV Shows, Radios And Posters