Allgorhythm said:I did it in two runs except, during my first run, I had to revert to save points when I did the achievements that required lethality and the ones that were mutually exclusive. The main path is fairly obvious. If you do Time Traveler, you lock yourself out of the Otus achievements so you have to do that as a branch. Similarly, with God Killer. You miss out on some e-books if you do that so you have to get the achievement and then revert to your main game save file.
The reason it took me three runs was because I went for God Killer on my first run.