Full list of all 50 Alien: Isolation achievements worth 1,000 gamerscore. It takes around 20-25 hours to unlock all of the achievements on Xbox 360.
Completed the game without killing any humans
Completed the game on the hardest difficulty setting
Killed by the Alien 100 times
Collected 10 Nostromo logs in the main campaign
Collected all ID tags
Completed the game without dying
Completed the game on any difficulty setting
Completed "Tomorrow, Together"
Completed "Desolation"
Completed "Transmission"
Completed "The Message"
Completed "The Descent"
Completed 10 minigames successfully
Navigated Reactor Maintenance without dying
Used the bolt gun
Completed "Consultation"
Collected 100 archive logs
Completed "A Synthetic Solution"
Completed "Hazard Containment"
Used the shotgun
Completed "The Trap"
Used the vent system 20 times
Constructed one of each craftable item
Caused the Alien to retreat by using the flamethrower
Used the flamethrower
Turned off the beacon
Detected 30 targets with the motion tracker
Completed "Seegson Synthetics"
Performed 10 successful hacks
Caused the Alien to retreat using a molotov
Killed 10 humans
Completed "The Outbreak"
Knocked down a human or stunned an android with a non-lethal attack
Used the stun baton
Accessed 10 different rewire points
Completed "The Quarantine"
Completed "The Quarantine" without being killed by the Alien
Completed "Seegson Communications"
Contacted your team and escaped Comms without being attacked by an android
Escaped from android combat without taking damage
Killed an android using only the maintenance jack
Killed an Android
Completed "Encounters"
Used the revolver
Encountered the Alien in Sevastopol for the first time
Completed "Welcome to Sevastopol"
Collected an ID tag
Constructed an item
Completed "Closing the Book"
Collected an archive log