Full list of all 50 Alien: Isolation achievements worth 1,000 gamerscore. It takes around 20-25 hours to unlock all of the achievements on Xbox 360.
Completed the game on any difficulty setting
Completed the game without killing any humans
Completed "Tomorrow, Together"
Completed "Desolation"
Completed "Transmission"
Completed "The Message"
Completed "The Descent"
Completed 10 minigames successfully
Used the bolt gun
Completed "Consultation"
Collected 100 archive logs
Completed "A Synthetic Solution"
Completed "Hazard Containment"
Killed an android using only the maintenance jack
Used the shotgun
Completed "The Trap"
Caused the Alien to retreat using a molotov
Caused the Alien to retreat by using the flamethrower
Killed by the Alien 100 times
Used the flamethrower
Turned off the beacon
Constructed one of each craftable item
Completed "Seegson Synthetics"
Performed 10 successful hacks
Completed "The Outbreak"
Used the stun baton
Knocked down a human or stunned an android with a non-lethal attack
Detected 30 targets with the motion tracker
Completed "The Quarantine"
Completed "Seegson Communications"
Accessed 10 different rewire points
Escaped from android combat without taking damage
Used the vent system 20 times
Killed an Android
Used the revolver
Completed "Encounters"
Encountered the Alien in Sevastopol for the first time
Completed "Welcome to Sevastopol"
Constructed an item
Collected an ID tag
Completed "Closing the Book"
Collected an archive log
Complete the game on the hardest difficulty setting
Collect all ID tags
Collect 10 Nostromo logs in the main campaign
Contact your team and escape Comms without being attacked by an android
Kill 10 humans
Navigate Reactor Maintenance without dying
Complete the fifth mission without being killed by the Alien
Complete the game without dying