Here is the full list of all 24 Big Pharma achievements worth 1,000 gamerscore.
Complete all the tutorial levels
Complete every challenge in the Beginner scenario
Complete every challenge in the intermediate scenario
Complete every challenge in the Advanced scenario
Complete every challenge in the Quick Start scenario
Complete every challenge in the Crippling Debt scenario
Complete every challenge in the Room to Maneuver scenario
Complete every challenge in the Full Unlock scenario
Take out all three loans at the same time
Successfully analyse at least 20 different effects within a single game
Use a Hadron Collider
Simultaneously sell one Pill, Cream, Syringe and Sachet
Simultaneously own 5 active patents
Purchase every available plot on a 3x3 or larger map
Sell a product which contains four different active catalysts
Sell a product which cures Alzheimer's Disease, Cures HIV and is a Cancer Vaccine
Sell a product which Reduces Anxiety and Enocurages Anxiety
Sell a product which Relieves Hypertension and Increases Blood Pressure
Sell a product which Eases Asthma and Causes Breathing Difficulties
Sell a product which Eases Migraine and Causes Headaches
Sell a product which Combats Cancer and is a Carcinogenic
Complete 20 challenges with an Expert rating
Complete 20 challenges with a Master rating
Include at least one random starting and disabled research in a custom game